South America offers some of the most dramatic trips available from the US. Peru and Machu Picchu need advance planning, Colombia is easier than many expect, and Buenos Aires and Rio make a strong city pairing.

You will find realistic itineraries, altitude notes and booking timelines.

Altitude affects Cusco, Machu Picchu and Bogotá. Give yourself a day to adjust, and book Machu Picchu permits well ahead.

The seasons differ by region: the Andes are driest from May to September, while Rio and Buenos Aires are best in spring and autumn.

Part of Mexico, Caribbean & Latin America guides. Browse the other topics there to keep planning.